Supplement evidence
Alpha-Ketoglutarate
The short answer
No use has passed JIVANA's study-level evidence review yet.
- Evidence and scope
- Research gathered — evidence review pending
This status does not grade the ingredient for every goal, outcome, or person.
- Important limitation
- No efficacy conclusion has passed JIVANA's study-level review yet. The linked research index is for discovery, not a benefit claim.
- Before deciding
- Identity, dose, interactions, product quality, and regulatory status still require review. Do not use this provisional page to decide whether to take it.
02 / EVIDENCE
What the research says
We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.
This research-index page is live so the topic, source trail, and evidence boundaries are visible. Individual studies have not yet passed the JIVANA extraction and review process, so we do not manufacture an efficacy conclusion or research count from broad search results.
Unscreened discovery appendix—not evidence58 candidate publicationsSearch run: Aug 21, 2026
Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.
03 / SOURCES
Start with the source material
The live search is for discovery only. Search-result counts change and are not included in the audited totals above.
Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
- Enhanced metabolic flexibility links Mediterranean diet with cognition: interim findings from a randomized controlled trial.Cruz M, Martínez-Huélamo M, Yubero-Serrano EM et al. · 2026 · Food & function · PMID 42504863Open on PubMed ↗
- Metabolic and Immunomodulatory Effects of α-Ketoglutarate in Burn Injuries: A Systematic Review.Niederegger T, Munzinger R, Schaschinger T et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association · PMID 41504365Open on PubMed ↗
- Does Nutrition Intervention Prevent and Heal Pressure Injury? A Systematic Review of Randomized Controlled Trials.Yildirim D, Akin E · 2026 · Advances in skin & wound care · PMID 41587302Open on PubMed ↗
- Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE).Lim ZM, Chew YE, Guan L et al. · 2025 · Experimental gerontology · PMID 40819772Open on PubMed ↗
- Biomarker discovery in NAFLD: insights from metabolomics and vote counting meta-analysis.Mudgal P, Kumar Gupta S, Malik S et al. · 2025 · Metabolomics : Official journal of the Metabolomic Society · PMID 40794151Open on PubMed ↗
- Proton-Nuclear Magnetic Resonance Metabolomics of Gingival Crevicular Fluid During Orthodontic Tooth Movement With Aligners.Domini MC, Castroflorio T, Deregibus A et al. · 2025 · Orthodontics & craniofacial research · PMID 40110902Open on PubMed ↗
- Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial.Kacerova T, Yates AG, Dai J et al. · 2025 · Alzheimer's & dementia : the journal of the Alzheimer's Association · PMID 40684250Open on PubMed ↗
- Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial.Cecchini M, Pilat MJ, Uboha N et al. · 2025 · Cancer · PMID 39917990Open on PubMed ↗
- Nutritional interventions in patients with burn injury: an umbrella review of systematic reviews and meta-analyses of randomised clinical trials.Naeini F, Zeraattalab-Motlagh S, Rahimlou M et al. · 2024 · The British journal of nutrition · PMID 39501634Open on PubMed ↗
- Exercise increases TCA intermediate concentrations during low-calorie diet independent of insulin resistance among women with obesity.Ragland TJ, Malin SK · 2024 · Physiological reports · PMID 38561248Open on PubMed ↗
- Nutritional interventions for preventing and treating pressure ulcers.Langer G, Wan CS, Fink A et al. · 2024 · The Cochrane database of systematic reviews · PMID 38345088Open on PubMed ↗
- Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism.Op den Kamp YJM, Gemmink A, de Ligt M et al. · 2022 · Molecular metabolism · PMID 36280113Open on PubMed ↗
04 / EXPERT CONTEXT
Expert context—not evidence
Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.
No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.