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Supplement evidence

144 / 575Botanical

American ginseng

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The short answer

Small trials examine post-meal glucose, fatigue, and respiratory outcomes; products vary.

Evidence and scope
Mixed evidence

This status does not grade the ingredient for every goal, outcome, or person.

Important limitation
Trials are inconsistent or small, so a reliable clinically important benefit is not established.
Before deciding
Key concern: Warfarin, diabetes medicines, autoimmune disease, insomnia, pregnancy, and hormone-sensitive conditions require review.

01 / PRACTICAL GUIDE

Dose, absorption, and combinations

These are indication-specific reference or studied ranges—not a personalized prescription. Start with the objective, then check the form, label, medicines, and health conditions.

Reference range by objective
Glucose-related research1–3 g root before a meal in small trials

Reference or studied range—not a personalized prescription. The product label or a clinician may specify a different dose.

Dose source

More is not automatically better. A clinician or product label may specify a different amount.

Absorption / solubilityFormulation-dependent

Not usefully classified as a fat- or water-soluble vitamin; absorption depends on the salt, extract, delivery system, and meal.

How it is commonly taken

Timing depends on the objective; use a standardized species-confirmed product.

Do not combine casually

Warfarin, diabetes medicines, autoimmune disease, insomnia, pregnancy, and hormone-sensitive conditions require review.

Dose and use source

Dose and use links lead to primary or official source material. Search links are discovery tools, not proof that every returned paper applies.

02 / EVIDENCE

What the research says

We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.

1research papers in this ledger
1unique primary studies represented
24unique participants represented

These are audited counts for this JIVANA collection, not search-result totals. Participants are counted once when multiple papers use the same cohort; review papers are not added again to participant totals.

Open the research timelineResearch timeline

Entries are ordered by publication year. A study period appears only when the source reports it.

2019
Mixed or qualifiedPMID 29478187 · NCT02923453

American ginseng extract as add-on treatment in type 2 diabetes

HbA1c fell by 0.29 percentage points and several secondary markers favored ginseng, but only 24 participants completed this crossover trial. The findings are hypothesis-strengthening, not sufficient to establish routine diabetes treatment or long-term safety.

Study design and methods
Design
Double-blind, randomized, placebo-controlled crossover trial
Population
24 adults with type 2 diabetes controlled by conventional treatment
Intervention
Standardized American ginseng extract 1 g with each meal (3 g/day) versus placebo as add-on therapy
Outcome
HbA1c, fasting glucose, blood pressure, lipids, and short-term liver and kidney safety markers

Funding or conflict note: One author was affiliated with Chai-Na-Ta Corp.; larger independent trials are needed.

Open research record
Unscreened discovery appendix—not evidence24 candidate publicationsSearch run: Aug 21, 2026

Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.

03 / SOURCES

Start with the source material

The live search is for discovery only. Search-result counts change and are not included in the audited totals above.

Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
  1. Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study.Best T, Miller J, Teo WP · 2024 · Nutritional neuroscience · PMID 38512715Open on PubMed
  2. Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study.Best T, Clarke C, Nuzum N et al. · 2021 · Nutritional neuroscience · PMID 31736428Open on PubMed
  3. Effects of Panax quinquefolius (American ginseng) on the steady state visually evoked potential during cognitive performance.White DJ, Camfield DA, Ossoukhova A et al. · 2020 · Human psychopharmacology · PMID 32896022Open on PubMed
  4. Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial.Guo M, Wang P, Du J et al. · 2020 · Pharmacological research · PMID 32446979Open on PubMed
  5. Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: A randomized controlled trial.Jovanovski E, Lea-Duvnjak-Smircic, Komishon A et al. · 2020 · Complementary therapies in medicine · PMID 32147072Open on PubMed
  6. The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention.Zhang DW, Wang SL, Wang PL et al. · 2020 · Journal of ethnopharmacology · PMID 31689480Open on PubMed
  7. Efficacy and safety of American ginseng (Panax quinquefolius L.) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial.Vuksan V, Xu ZZ, Jovanovski E et al. · 2019 · European journal of nutrition · PMID 29478187Open on PubMed
  8. Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial.Jenkins AL, Morgan LM, Bishop J et al. · 2018 · European journal of nutrition · PMID 28687934Open on PubMed
  9. Effect of Xinyue capsules on patients with coronary heart disease after percutaneous coronary intervention: study protocol for a randomized controlled trial.Guo M, Zi MJ, Xi RX et al. · 2016 · Trials · PMID 27538952Open on PubMed
  10. Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults.Ossoukhova A, Owen L, Savage K et al. · 2015 · Human psychopharmacology · PMID 25778987Open on PubMed
  11. Ethanol extraction preparation of American ginseng (Panax quinquefolius L) and Korean red ginseng (Panax ginseng C.A. Meyer): differential effects on postprandial insulinemia in healthy individuals.De Souza LR, Jenkins AL, Jovanovski E et al. · 2015 · Journal of ethnopharmacology · PMID 25446600Open on PubMed
  12. American ginseng tea protects cellular DNA within 2 h from consumption: results of a pilot study in healthy human volunteers.Szeto YT, Sin YS, Pak SC et al. · 2015 · International journal of food sciences and nutrition · PMID 26393910Open on PubMed

04 / EXPERT CONTEXT

Expert context—not evidence

Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.

No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.

Educational information only—not medical advice. Product quality, dose, medicines, pregnancy, and kidney or liver disease can materially change safety.