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Supplement evidence

180 / 575Research index — evidence review pending

Avocado/Soybean Unsaponifiables

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The short answer

No use has passed JIVANA's study-level evidence review yet.

Evidence and scope
Research gathered — evidence review pending

This status does not grade the ingredient for every goal, outcome, or person.

Important limitation
No efficacy conclusion has passed JIVANA's study-level review yet. The linked research index is for discovery, not a benefit claim.
Before deciding
Identity, dose, interactions, product quality, and regulatory status still require review. Do not use this provisional page to decide whether to take it.

02 / EVIDENCE

What the research says

We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.

Study-level extraction is not complete yet.

This research-index page is live so the topic, source trail, and evidence boundaries are visible. Individual studies have not yet passed the JIVANA extraction and review process, so we do not manufacture an efficacy conclusion or research count from broad search results.

Unscreened discovery appendix—not evidence19 candidate publicationsSearch run: Aug 21, 2026

Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.

03 / SOURCES

Start with the source material

The live search is for discovery only. Search-result counts change and are not included in the audited totals above.

Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
  1. Safety of Anti-osteoarthritis Medications: A Systematic Literature Review of Post-marketing Surveillance Studies.Honvo G, Lengelé L, Alokail M et al. · 2025 · Drugs · PMID 40095377Open on PubMed
  2. Efficacy and safety of avocado-soybean unsaponifiables for the treatment of hip and knee osteoarthritis: A systematic review and meta-analysis of randomized placebo-controlled trials.Simental-Mendía M, Sánchez-García A, Acosta-Olivo CA et al. · 2019 · International journal of rheumatic diseases · PMID 31328413Open on PubMed
  3. Conditional Recommendations for Specific Dietary Ingredients as an Approach to Chronic Musculoskeletal Pain: Evidence-Based Decision Aid for Health Care Providers, Participants, and Policy Makers.Boyd C, Crawford C, Berry K et al. · 2019 · Pain medicine (Malden, Mass.) · PMID 30986301Open on PubMed
  4. Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.Honvo G, Reginster JY, Rabenda V et al. · 2019 · Drugs & aging · PMID 31073924Open on PubMed
  5. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.Liu X, Machado GC, Eyles JP et al. · 2018 · British journal of sports medicine · PMID 29018060Open on PubMed
  6. Supplementary methods in the nonsurgical treatment of osteoarthritis.Percope de Andrade MA, Campos TV, Abreu-E-Silva GM · 2015 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · PMID 25633815Open on PubMed
  7. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity.Martínez-Abundis E, González-Ortiz M, Mercado-Sesma AR et al. · 2013 · Obesity facts · PMID 24135894Open on PubMed
  8. Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products.Henrotin Y, Lambert C, Couchourel D et al. · 2011 · Osteoarthritis and cartilage · PMID 21035558Open on PubMed
  9. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part I: Osteoarthritis.Cameron M, Gagnier JJ, Little CV et al. · 2009 · Phytotherapy research : PTR · PMID 19856319Open on PubMed
  10. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.Bruyère O, Burlet N, Delmas PD et al. · 2008 · BMC musculoskeletal disorders · PMID 19087296Open on PubMed
  11. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials.Christensen R, Bartels EM, Astrup A et al. · 2008 · Osteoarthritis and cartilage · PMID 18042410Open on PubMed
  12. Effectiveness of nonpharmacological and nonsurgical interventions for hip osteoarthritis: an umbrella review of high-quality systematic reviews.Moe RH, Haavardsholm EA, Christie A et al. · 2007 · Physical therapy · PMID 17906289Open on PubMed

04 / EXPERT CONTEXT

Expert context—not evidence

Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.

No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.

Educational information only—not medical advice. Product quality, dose, medicines, pregnancy, and kidney or liver disease can materially change safety.