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Supplement evidence

124 / 575Plant compound

Broccoli sprout extract

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The short answer

A precursor-delivery product whose active sulforaphane yield varies widely.

Evidence and scope
Emerging evidence

This status does not grade the ingredient for every goal, outcome, or person.

Important limitation
Early human findings are hypothesis-generating; efficacy, long-term safety, and optimal dose remain uncertain.
Before deciding
Key concern: Same cautions as sulforaphane; raw-sprout contamination matters in pregnancy or immunocompromise.

01 / PRACTICAL GUIDE

Dose, absorption, and combinations

These are indication-specific reference or studied ranges—not a personalized prescription. Start with the objective, then check the form, label, medicines, and health conditions.

Reference range by objective
Meeting usual needsUse a product reporting sulforaphane yield, not only glucoraphanin milligrams

Reference or studied range—not a personalized prescription. The product label or a clinician may specify a different dose.

Dose source

More is not automatically better. A clinician or product label may specify a different amount.

Absorption / solubilityFormulation-dependent

Not usefully classified as a fat- or water-soluble vitamin; absorption depends on the salt, extract, delivery system, and meal.

How it is commonly taken

Take as studied; myrosinase content is decisive.

Do not combine casually

Same cautions as sulforaphane; raw-sprout contamination matters in pregnancy or immunocompromise.

Dose and use source

Dose and use links lead to primary or official source material. Search links are discovery tools, not proof that every returned paper applies.

02 / EVIDENCE

What the research says

We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.

1research papers in this ledger
1unique primary studies represented
291unique participants represented

These are audited counts for this JIVANA collection, not search-result totals. Participants are counted once when multiple papers use the same cohort; review papers are not added again to participant totals.

Open the research timelineResearch timeline

Entries are ordered by publication year. A study period appears only when the source reports it.

2014
Mixed or qualifiedPMID 24913818

Broccoli sprout beverage and airborne-pollutant excretion

Excretion biomarkers rose for benzene by 61% and acrolein by 23%, but not crotonaldehyde. This demonstrates short-term pharmacodynamic activity in a high-exposure setting, not reduced cancer, lung disease, cardiovascular events, or mortality.

Study design and methods
Design
Randomized controlled clinical trial
Population
291 adults in a rural Chinese region with substantial airborne-pollutant exposure
Intervention
Broccoli sprout beverage providing 600 μmol glucoraphanin and 40 μmol sulforaphane daily versus placebo
Outcome
Urinary excretion biomarkers for benzene, acrolein, and crotonaldehyde
Open research record
Unscreened discovery appendix—not evidence15 candidate publicationsSearch run: Aug 21, 2026

Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.

03 / SOURCES

Start with the source material

The live search is for discovery only. Search-result counts change and are not included in the audited totals above.

Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
  1. Effects of Broccoli Sprout Supplementation and Pilates Training on Liver Enzymes in Women with Nonalcoholic Fatty Liver Disease: A Double-Blind, Randomized Controlled Trial.Ghorbanian K, Tavakoli N, Alam PS et al. · 2026 · Plant foods for human nutrition (Dordrecht, Netherlands) · PMID 42228225Open on PubMed
  2. Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial.Dwibedi C, Axelsson AS, Abrahamsson B et al. · 2025 · Nature microbiology · PMID 39929977Open on PubMed
  3. A Presurgical-Window Intervention Trial of Isothiocyanate-Rich Broccoli Sprout Extract in Patients with Breast Cancer.Wang Z, Tu C, Pratt R et al. · 2022 · Molecular nutrition & food research · PMID 35475592Open on PubMed
  4. The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis.Yusin J, Wang V, Henning SM et al. · 2021 · Nutrients · PMID 33920642Open on PubMed
  5. Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy.Chang YW, Park YM, Oh CH et al. · 2020 · The Korean journal of internal medicine · PMID 31830776Open on PubMed
  6. Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial.Zhang Z, Garzotto M, Davis EW 2nd et al. · 2020 · Nutrition and cancer · PMID 31155953Open on PubMed
  7. Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi.Tahata S, Singh SV, Lin Y et al. · 2018 · Cancer prevention research (Philadelphia, Pa.) · PMID 29691233Open on PubMed
  8. Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders.Kerns ML, Guss L, Fahey J et al. · 2017 · Journal of the American Academy of Dermatology · PMID 27889290Open on PubMed
  9. Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.Wise RA, Holbrook JT, Criner G et al. · 2016 · PloS one · PMID 27832073Open on PubMed
  10. Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials.van Die MD, Bone KM, Emery J et al. · 2016 · BJU international · PMID 26898239Open on PubMed
  11. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects.Kikuchi M, Ushida Y, Shiozawa H et al. · 2015 · World journal of gastroenterology · PMID 26604653Open on PubMed
  12. The Effects of Broccoli Sprout Extract Containing Sulforaphane on Lipid Peroxidation and Helicobacter pylori Infection in the Gastric Mucosa.Chang YW, Jang JY, Kim YH et al. · 2015 · Gut and liver · PMID 25287166Open on PubMed

04 / EXPERT CONTEXT

Expert context—not evidence

Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.

No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.

Educational information only—not medical advice. Product quality, dose, medicines, pregnancy, and kidney or liver disease can materially change safety.