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Supplement evidence

088 / 575Mood & stress

Oral lavender oil

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The short answer

A standardized oral lavender-oil preparation has evidence for anxiety symptoms; aromatherapy is a different intervention.

Evidence and scope
Conditional or population-specific

This status does not grade the ingredient for every goal, outcome, or person.

Important limitation
Benefit depends on the population, formulation, baseline status, and objective; results should not be generalized.
Before deciding
Key concern: Sedatives, pregnancy, hormone-sensitive conditions, and surgery require caution.

01 / PRACTICAL GUIDE

Dose, absorption, and combinations

These are indication-specific reference or studied ranges—not a personalized prescription. Start with the objective, then check the form, label, medicines, and health conditions.

Reference range by objective
Mood symptoms80 mg/day standardized oral preparation; some trials use 160 mg/day

Reference or studied range—not a personalized prescription. The product label or a clinician may specify a different dose.

Dose source

More is not automatically better. A clinician or product label may specify a different amount.

Absorption / solubilityFat-soluble / lipid-based

Fat-soluble or lipid-based. Absorption generally improves with a meal containing fat.

How it is commonly taken

Swallow the studied enteric-coated product; do not ingest essential oil products not made for oral use.

Do not combine casually

Sedatives, pregnancy, hormone-sensitive conditions, and surgery require caution.

Dose and use source

Dose and use links lead to primary or official source material. Search links are discovery tools, not proof that every returned paper applies.

02 / EVIDENCE

What the research says

We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.

1research papers in this ledger
5unique primary studies represented
1,213unique participants represented

These are audited counts for this JIVANA collection, not search-result totals. Participants are counted once when multiple papers use the same cohort; review papers are not added again to participant totals.

Open the research timelineResearch timeline

Entries are ordered by publication year. A study period appears only when the source reports it.

2023
Supports a specific usePMID 36717399

Efficacy of oral Silexan in patients with anxiety disorders

Silexan improved clinician- and self-rated anxiety and quality-of-life measures; adverse events and withdrawals did not clearly differ. The result applies to this proprietary oral product, not inhaled lavender or arbitrary oils.

Study design and methods
Design
Individual-patient meta-analysis of 5 double-blind randomized placebo-controlled trials
Population
1,213 adult outpatients with subthreshold anxiety, mixed anxiety and depressive disorder, or generalized anxiety disorder
Intervention
Proprietary oral lavender-oil preparation Silexan 80 mg/day versus placebo
Outcome
Clinician- and self-rated anxiety, global improvement, quality of life, and adverse events

Funding or conflict note: One author was an employee of Silexan manufacturer Dr. Willmar Schwabe; several authors reported Schwabe relationships.

Open research record
Unscreened discovery appendix—not evidence18 candidate publicationsSearch run: Aug 21, 2026

Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.

03 / SOURCES

Start with the source material

The live search is for discovery only. Search-result counts change and are not included in the audited totals above.

Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
  1. Aromatherapy with lavender essential oil for the control of dental anxiety in patients undergoing dental surgery: A triple-blind randomized clinical trial.Argueta-Figueroa L, Ávila-Curiel BX, Vera-Juárez EM et al. · 2026 · Dental and medical problems · PMID 41553229Open on PubMed
  2. Aromatherapy on Anxiety, Pain, and Quality of Life Following Surgery of Mandibular Third Molars: A Randomized, Double-Blind Clinical Trial.Matos YR, Nascimento MFDS, Gomes MCM et al. · 2025 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · PMID 40147494Open on PubMed
  3. Anti-nociceptive efficacy of essential oil-based extracts for the management of orofacial pain: a systematic review of available evidence.Javed F, Bello-Correa FO, Nikolaidou A et al. · 2021 · European review for medical and pharmacological sciences · PMID 34919232Open on PubMed
  4. The Effect of Lavender Oil on Perioperative Pain, Anxiety, Depression, and Sleep after Microvascular Breast Reconstruction: A Prospective, Single-Blinded, Randomized, Controlled Trial.Shammas RL, Marks CE, Broadwater G et al. · 2021 · Journal of reconstructive microsurgery · PMID 33548936Open on PubMed
  5. No Abuse Potential of Silexan in Healthy Recreational Drug Users: A Randomized Controlled Trial.Seifritz E, Möller HJ, Volz HP et al. · 2021 · The international journal of neuropsychopharmacology · PMID 33300578Open on PubMed
  6. The effectiveness of aromatherapy on preoperative anxiety in adults: A systematic review and meta-analysis of randomized controlled trials.Guo P, Li P, Zhang X et al. · 2020 · International journal of nursing studies · PMID 32861206Open on PubMed
  7. Can lavender oil inhalation help to overcome dental anxiety and pain in children? A randomized clinical trial.Arslan I, Aydinoglu S, Karan NB · 2020 · European journal of pediatrics · PMID 32030454Open on PubMed
  8. The best route of administration of lavender for anxiety: a systematic review and network meta-analysis.Sayed AM, Morsy S, Tawfik GM et al. · 2020 · General hospital psychiatry · PMID 32088511Open on PubMed
  9. Effects of lavender on anxiety: A systematic review and meta-analysis.Donelli D, Antonelli M, Bellinazzi C et al. · 2019 · Phytomedicine : international journal of phytotherapy and phytopharmacology · PMID 31655395Open on PubMed
  10. Effect of Lavender Oil Inhalation on Reducing Presurgical Anxiety in Orthognathic Surgery Patients.Bozkurt P, Vural Ç · 2019 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · PMID 31574261Open on PubMed
  11. Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial.Karan NB · 2019 · Physiology & behavior · PMID 31505191Open on PubMed
  12. Efficacy of Silexan in subthreshold anxiety: meta-analysis of randomised, placebo-controlled trials.Möller HJ, Volz HP, Dienel A et al. · 2019 · European archives of psychiatry and clinical neuroscience · PMID 29150713Open on PubMed

04 / EXPERT CONTEXT

Expert context—not evidence

Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.

No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.

Educational information only—not medical advice. Product quality, dose, medicines, pregnancy, and kidney or liver disease can materially change safety.