The short answer
Trials examine glucose, vascular, and inflammatory markers with inconsistent results.
- Evidence and scope
- Mixed evidence
This status does not grade the ingredient for every goal, outcome, or person.
- Important limitation
- Animal mechanisms and biomarker changes have not established human lifespan extension.
- Before deciding
- GI effects and interactions with anticoagulants and drug-metabolizing enzymes are concerns.
01 / PRACTICAL GUIDE
Dose, absorption, and combinations
These are indication-specific reference or studied ranges—not a personalized prescription. Start with the objective, then check the form, label, medicines, and health conditions.
Reference or studied range—not a personalized prescription. The product label or a clinician may specify a different dose.
Dose source ↗More is not automatically better. A clinician or product label may specify a different amount.
Fat-soluble or lipid-based. Absorption generally improves with a meal containing fat.
Take with food; formulation changes exposure.
Anticoagulants, estrogen-sensitive conditions, surgery, CYP interactions, pregnancy, and cancer therapy require review.
Dose and use links lead to primary or official source material. Search links are discovery tools, not proof that every returned paper applies.
02 / EVIDENCE
What the research says
We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.
These are audited counts for this JIVANA collection, not search-result totals. Participants are counted once when multiple papers use the same cohort; review papers are not added again to participant totals.
Open the research timelineResearch timeline+
Entries are ordered by publication year. A study period appears only when the source reports it.
Resveratrol for the Management of Human Health: How Far Have We Come?
The review found no conclusive clinical evidence supporting recommendation in a healthcare setting and called for larger, higher-quality trials.
Study design and methods
- Design
- Systematic review of clinical trials across indications
- Population
- Multiple human populations
- Intervention
- Purified resveratrol at defined doses
- Outcome
- Multiple clinical and biomarker outcomes
Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women
The study reported small improvements in cognition and several secondary vascular or metabolic measures in this population.
Study design and methods
- Design
- Randomized, double-blind, placebo-controlled crossover trial
- Population
- Postmenopausal women aged 45–85
- Intervention
- Trans-resveratrol 150 mg/day versus placebo
- Outcome
- Cognition and cerebrovascular function
Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults
The trial did not show significant improvement in its main verbal-memory outcome.
Study design and methods
- Design
- Randomized, double-blind, placebo-controlled trial
- Population
- Adults aged 60–79
- Intervention
- Resveratrol 200 mg/day versus placebo
- Outcome
- Verbal memory and brain imaging
Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
The small trial reported improved memory performance and related surrogate measures.
Study design and methods
- Design
- Randomized, double-blind, placebo-controlled trial
- Population
- Healthy overweight older adults
- Intervention
- Resveratrol 200 mg/day versus placebo
- Outcome
- Memory and hippocampal connectivity
High-dose resveratrol supplementation in obese men
No meaningful metabolic benefit was demonstrated over four weeks.
Study design and methods
- Design
- Randomized, double-blind, placebo-controlled trial
- Population
- Obese but otherwise healthy men
- Intervention
- High-dose resveratrol versus placebo
- Outcome
- Insulin sensitivity, metabolism, and body composition
Unscreened discovery appendix—not evidence530 candidate publicationsSearch run: Aug 21, 2026
Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.
03 / SOURCES
Start with the source material
The live search is for discovery only. Search-result counts change and are not included in the audited totals above.
Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
- Conventional and nonconventional therapies for pesticide-induced cardiotoxicity: A systematic review.de Almeida DL, da Costa SJG, Silva VC et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · PMID 42508715Open on PubMed ↗
- Autophagy potential of polyphenols in breast carcinoma: A systematic review.Golchin A, Teymori Nobari S, Maleki M et al. · 2026 · Pathology, research and practice · PMID 42475944Open on PubMed ↗
- Protocol for a randomized, controlled trial of a bioactive dietary polyphenol preparation to promote resilience in healthy individuals.Marchidan MM, Rizk MM, Karpman E et al. · 2026 · Contemporary clinical trials · PMID 42320787Open on PubMed ↗
- Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.Su SY, Tzeng IS, Huang TH et al. · 2026 · Nutrients · PMID 42451212Open on PubMed ↗
- Contribution of Resveratrol on Periodontal Disease Control and Treatment: A Systematic Review.Bandiaky ON, Bechina C, Vanden Berghe M et al. · 2026 · Oral health & preventive dentistry · PMID 42384081Open on PubMed ↗
- Resveratrol supplementation and assisted reproduction outcomes: A systematic review and meta-analysis.Lemos MJ, Oliveira JA, Queiroz LF et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology · PMID 42150354Open on PubMed ↗
- Effects of turmeric and curcumin in patients on dialysis or using immunosuppressive agents: a systematic review.Rajabian F, Khajavi Rad A, Ghorban Sabbagh M et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology · PMID 42047771Open on PubMed ↗
- Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial.García-Nicolás M, Jarrín-Orozco MP, Romo-Vaquero M et al. · 2026 · European journal of nutrition · PMID 42371155Open on PubMed ↗
- The Gut-Bone Axis and Skeletal Health: Regulatory Mechanisms and Therapeutic Applications of Plant-Derived Bioactive Compounds.Zhang T, Li Y, Pei J et al. · 2026 · Biomolecules · PMID 42352378Open on PubMed ↗
- The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis.Ghalichi F, Molani-Gol R, Tejareh F et al. · 2026 · Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · PMID 42268476Open on PubMed ↗
- The neuroprotective and therapeutic potential of resveratrol for traumatic spinal cord injuries: a systematic review.Moselmani M, Khayat D, Ajami S et al. · 2026 · BMC neurology · PMID 42265649Open on PubMed ↗
- The proBNPage reduction (PBAR) trial-results of a randomized, double blind, placebo-controlled, pilot study to fine tune an NT-proBNP-based method to assess the effect of anti-aging treatments.Muscari A, Forti P, Magalotti D et al. · 2026 · GeroScience · PMID 40922000Open on PubMed ↗
04 / EXPERT CONTEXT
Expert context—not evidence
Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.
No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.