Supplement evidence

016 / 575Vitamin

Vitamin B6

View my plan →

The short answer

Preventing or treating deficiency in selected medical and dietary contexts.

Evidence and scope: Established for an indicated use
This status does not grade the ingredient for every goal, outcome, or person.
Important limitation: It has not shown broad prevention or longevity benefits in replete adults.
Before deciding: Chronic high doses can cause potentially irreversible sensory neuropathy.

01 / PRACTICAL GUIDE

Dose, absorption, and combinations

These are indication-specific reference or studied ranges—not a personalized prescription. Start with the objective, then check the form, label, medicines, and health conditions.

Reference range by objective

Meeting usual needsAbout 1.3–1.7 mg/day depending on age and sex

Reference or studied range—not a personalized prescription. The product label or a clinician may specify a different dose.

Dose source ↗

More is not automatically better. A clinician or product label may specify a different amount.

Absorption / solubilityWater-soluble

Water-soluble or readily water-dispersible. This does not mean excess is always harmless.

How it is commonly taken

May be taken with food.

Do not combine casually

Avoid chronic high-dose stacking; sensory neuropathy can occur and medicines may also contain B6.

Dose and use source ↗

Dose and use links lead to primary or official source material. Search links are discovery tools, not proof that every returned paper applies.

02 / EVIDENCE

What the research says

We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.

4research papers in this ledger

5unique primary studies represented

91unique participants represented

These are audited counts for this JIVANA collection, not search-result totals. Participants are counted once when multiple papers use the same cohort; review papers are not added again to participant totals.

Open the research timelineResearch timeline

Entries are ordered by publication year. A study period appears only when the source reports it.

2023

Safety signalPMID 37447150

The Role of Vitamin B6 in Peripheral Neuropathy

High B6 levels, usually associated with supplements, were linked to predominantly sensory axonal neuropathy and symptoms often improved after stopping. Evidence did not establish B6 monotherapy as a neuropathy treatment.

Published: 202320 primary studies represented

Study design and methods

Design: Systematic review of 20 heterogeneous clinical articles
Population: People with peripheral neuropathy or high or low vitamin B6 status
Intervention: Supplement exposure, discontinuation, or B6-containing combination treatment
Outcome: Peripheral-neuropathy type, symptoms, causality, and recovery

Funding or conflict note: The authors declared no conflict of interest. Heterogeneous observational and treatment reports are not counted as randomized represented studies.

Open research record ↗

2007

Does not support the tested claimPMID 17210874

Vitamin B6, B12, and folic acid supplementation and cognitive function

The three B6 monotherapy trials found no overall cognitive benefit; combination trials also found no overall effect. Evidence was sparse, small, heterogeneous, and did not establish meaningful clinical outcomes.

Published: 20073 primary studies represented

Study design and methods

Design: Systematic review of randomized trials, including three vitamin B6 monotherapy trials
Population: People with normal or impaired cognition across small, heterogeneous trials
Intervention: Vitamin B6 alone or B-vitamin combinations versus control
Outcome: Approximately 50 cognitive-function tests

Funding or conflict note: Only the three B6 monotherapy trials are counted; six combination trials are context only because an isolated B6 effect cannot be assigned.

Open research record ↗

1993

Does not support the tested claimPMID 8219859

Using pyridoxine to treat carpal tunnel syndrome

No outcome differed between pyridoxine and placebo. This small trial does not support pyridoxine for idiopathic carpal tunnel syndrome when deficiency is not established.

Published: 1993n=32 participants

Study design and methods

Design: Randomized placebo-controlled trial
Population: 32 patients with idiopathic carpal tunnel syndrome
Intervention: Pyridoxine treatment or placebo
Outcome: Electrophysiologic signs, clinical signs, and symptoms

Open research record ↗

1991

Mixed or qualifiedPMID 2047064

Vitamin B6 is effective therapy for nausea and vomiting of pregnancy

Severe nausea improved more with pyridoxine, while mild-to-moderate nausea and the overall group did not differ significantly. Fewer women reported vomiting after treatment, but the trial was small and short.

Published: 1991Duration: 72 hoursn=59 participants

Study design and methods

Design: Randomized, double-blind, placebo-controlled trial
Population: 59 pregnant women who completed the trial
Intervention: Pyridoxine 25 mg every eight hours or placebo
Outcome: Nausea severity and vomiting over 72 hours

Open research record ↗

Unscreened discovery appendix—not evidence936 candidate publicationsSearch run: Aug 21, 2026

Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.

03 / SOURCES

Start with the source material

Official evidence overviewNIH Office of Dietary Supplements Live PubMed discovery searchNational Library of Medicine

The live search is for discovery only. Search-result counts change and are not included in the audited totals above.

Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.

04 / EXPERT CONTEXT

Expert context—not evidence

Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.

No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.