The short answer
Conveniently meeting protein needs when food intake is insufficient, especially alongside resistance training.
- Evidence and scope
- Conditional or population-specific
This status does not grade the ingredient for every goal, outcome, or person.
- Important limitation
- It offers little advantage over adequate high-quality food protein and is not independently proven to extend life.
- Before deciding
- Choose tested products; kidney disease and some metabolic disorders require individualized advice.
01 / PRACTICAL GUIDE
Dose, absorption, and combinations
These are indication-specific reference or studied ranges—not a personalized prescription. Start with the objective, then check the form, label, medicines, and health conditions.
Reference or studied range—not a personalized prescription. The product label or a clinician may specify a different dose.
Dose source ↗More is not automatically better. A clinician or product label may specify a different amount.
Fat/water solubility is not the useful decision point; preparation, fluid, timing, or strain identity matters more.
Use to fill a dietary gap; distribute across meals.
Kidney disease, metabolic disorders, allergies, and contaminated products require individualized review.
Dose and use links lead to primary or official source material. Search links are discovery tools, not proof that every returned paper applies.
02 / EVIDENCE
What the research says
We keep supportive, mixed, negative, safety, and contextual findings together. The headline never replaces the underlying papers.
These are audited counts for this JIVANA collection, not search-result totals. Participants are counted once when multiple papers use the same cohort; review papers are not added again to participant totals.
Open the research timelineResearch timeline+
Entries are ordered by publication year. A study period appears only when the source reports it.
A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults
Supplementation added small gains in strength, fat-free mass, and muscle size during resistance training; the dose-response analysis estimated a plateau near 1.62 g/kg/day of total protein intake.
Study design and methods
- Design
- Systematic review, meta-analysis, and meta-regression
- Population
- Healthy adults performing prolonged resistance training
- Intervention
- Dietary protein supplementation during resistance training versus control
- Outcome
- Strength, fat-free mass, and muscle size
Effects of protein supplementation on lean body mass, muscle strength, and physical performance in nonfrail community-dwelling older adults
No significant improvement was found across muscle mass, strength, or physical-performance outcomes. The result may not apply to older adults with low baseline protein intake.
Study design and methods
- Design
- Systematic review and meta-analysis
- Population
- Nonfrail, community-dwelling older adults, most with sufficient habitual protein intake
- Intervention
- Protein supplementation with or without resistance training versus control
- Outcome
- Lean mass, strength, gait speed, and chair-rise ability
Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets
Kidney-function changes did not differ between diets in adults without kidney disease. This does not establish safety for people with chronic kidney disease.
Study design and methods
- Design
- Systematic review and meta-analysis of randomized trials
- Population
- Adults without chronic kidney disease
- Intervention
- Higher-protein diets versus lower- or normal-protein diets
- Outcome
- Glomerular filtration rate and other kidney-function measures
Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials
With calories intentionally restricted in both groups, higher-protein diets produced modestly greater weight and fat loss and better preservation of fat-free mass and resting energy expenditure.
Study design and methods
- Design
- Meta-analysis of randomized energy-restricted diet trials
- Population
- Adults in energy-restricted weight-loss trials
- Intervention
- Higher-protein, low-fat diet versus standard-protein, low-fat diet
- Outcome
- Body weight, fat mass, fat-free mass, resting energy expenditure, and cardiometabolic markers
Unscreened discovery appendix—not evidence1,371 candidate publicationsSearch run: Aug 21, 2026
Complete for the displayed PubMed query at the search timestamp—not for all databases or every possible synonym. Candidates can be irrelevant, duplicate the same study, or report negative findings. They are never summed as evidence or participants until screened.
03 / SOURCES
Start with the source material
The live search is for discovery only. Search-result counts change and are not included in the audited totals above.
Recent PubMed discovery recordsDirect links to the first 12 records returned by the reproducible search. These are discovery candidates—not reviewed summaries or a count of supportive findings.
- Bifidobacterium longum BB536 is associated with improvements in gastrointestinal symptoms and odor-related metabolites in microbiota-defined subgroups of male athletes consuming a high-protein diet: exploratory randomized double‑blind placebo‑controlled trial.Miyamoto S, Yoshimoto S, Katsumata N et al. · 2026 · Journal of the International Society of Sports Nutrition · PMID 42046285Open on PubMed ↗
- Whey protein intakes up to 0.4g/kg body mass are well tolerated before a 10km run at 85% of race pace: a clinical trial.Shaw K, Lindstrom B, Moss A et al. · 2026 · Journal of the International Society of Sports Nutrition · PMID 41556283Open on PubMed ↗
- The effectiveness of protein supplements on athletic performance and post-exercise recovery - a Bayesian multilevel meta-analysis of randomized controlled trials.Zhao S, Zhang X, Liang T et al. · 2026 · Journal of the International Society of Sports Nutrition · PMID 41433039Open on PubMed ↗
- Presleep Whey but Not Casein Protein Ingestion Improves Sleep Quality After Resistance Exercise When Compared With an Isocaloric Control in Resistance Trained Individuals.Aussieker T, Kredig N, Wasserfurth P et al. · 2026 · International journal of sport nutrition and exercise metabolism · PMID 42413910Open on PubMed ↗
- Investigating the Effects of a Novel Salmon-Derived Protein Peptide on Markers of Recovery From Exercise-Induced Muscle Damage.Haigney E, Waddell A, Korzepa M et al. · 2026 · International journal of sport nutrition and exercise metabolism · PMID 42248424Open on PubMed ↗
- Prognostic effects of NRS 2002- and GLIM-guided nutritional intervention in patients undergoing intracranial tumor surgery: A non-randomized controlled study.Han J, Zhou X, Xu W et al. · 2026 · Clinical neurology and neurosurgery · PMID 42150221Open on PubMed ↗
- Synergistic effects of synbiotic, protein supplementation, and resistance training on inflammation, oxidative stress, and muscle strength in older adults with type 2 diabetes mellitus: a RCT triple-blinded study.Bastos MF, Longo PL, Furtado GE et al. · 2026 · European journal of nutrition · PMID 42616143Open on PubMed ↗
- Dietary Intake of Animal and Plant-Based Protein on Adiposity Measurements and Body Composition in Pre- and Postmenopausal Women: A Systematic Review of Randomized Clinical Trials.Fialho SN, de Souza Ferreira ML, Ribeiro SAV et al. · 2026 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · PMID 42541706Open on PubMed ↗
- Nutritional interventions and dietary supplements in muscle diseases: a systematic review.Talreja T, Vedantam D, Bandarupalli P et al. · 2026 · Rheumatology (Oxford, England) · PMID 42482152Open on PubMed ↗
- A Systematic Review to Reassess the Formula for Early Life Growth.Nilaweera KN, van Sinderen D, Cotter PD · 2026 · Advances in nutrition (Bethesda, Md.) · PMID 42176955Open on PubMed ↗
- Assessing the responsiveness of musculoskeletal tissues to protein supplementation in vivo in older adults: an exploratory randomized controlled trial.Houtvast DC, Hendriks FK, Weijzen ME et al. · 2026 · The American journal of clinical nutrition · PMID 42142739Open on PubMed ↗
- Effect of Whey and Soy Protein Supplements on Inflammation in Adults on Chronic Hemodialysis: A Double-blind Randomized Crossover Controlled Study.Aycart DF, Acevedo S, Ilkun O et al. · 2026 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · PMID 41759604Open on PubMed ↗
04 / EXPERT CONTEXT
Expert context—not evidence
Expert positions are dated context—not scientific evidence. They never raise the evidence status or become consensus by repetition.
No direct, source-verified endorsement is currently recorded. Research authorship or discussion alone is not treated as endorsement.