Research review priorities
Supplement research priorities
These are research priorities, not recommendations. We selected decisions where public interest, plausible benefit, evidence maturity, and safety stakes make a careful synthesis especially useful.
- priority dossiers
- 148
- claim-level questions
- 444
- study extraction underway
- 148
01 / PRIORITY
How priorities were selected
Priority reflects relevance to healthy aging, frequency of real-world use, maturity of human evidence, the cost of a wrong decision, and the need to separate a valid narrow use from broader marketing claims. It does not rank efficacy or imply that everyone should take the product.
02 / EXTRACTION
What happens next
For every question, we screen the PubMed candidate set, connect multiple publications from the same trial, extract population, dose, comparator, duration, outcomes, harms, and funding, then synthesize supportive, mixed, negative, and safety findings together.
Only screened studies enter audited study and participant totals. Search-result counts and the papers listed here as questions never become evidence by themselves.Spermidine
- Review stage
- Extracting studies
- audited research papers
- 4
Why this is a research priority
Autophagy and longevity narratives rely heavily on models and biomarkers; the limited human trials require separation of cognition, hair endpoints, and multi-ingredient products.
Questions being reviewed
- Does spermidine improve memory in older adults with subjective cognitive decline?
- Do autophagy, inflammation, or biological-age biomarkers establish longer or healthier life?
- Does a spermidine-containing product improve clinically meaningful hair outcomes, and can the effect be isolated?
Nicotinamide riboside (NR)
- Review stage
- Extracting studies
- audited research papers
- 4
Why this is a research priority
Nicotinamide riboside reliably raises NAD-related metabolites, but biomarker target engagement is often presented as proven metabolic, cognitive, cardiovascular, or longevity benefit.
Questions being reviewed
- Which doses raise NAD⁺, in which tissues, and does that biomarker change improve health?
- Does NR improve insulin sensitivity, body composition, blood pressure, or mitochondrial function?
- Does NR improve cognition, physical function, or clinically measured healthy aging?
Branched-chain amino acids (BCAAs)
- Review stage
- Extracting studies
- audited research papers
- 4
Why this is a research priority
BCAAs may modestly alter soreness or muscle-damage biomarkers, but adequate complete protein and actual performance outcomes are often omitted from marketing claims.
Questions being reviewed
- Do BCAAs reduce soreness and muscle-damage biomarkers after strenuous exercise?
- Do those changes improve strength, performance, or body composition?
- Is there added benefit when total daily protein and essential amino acids are already adequate?
Magnesium glycinate
- Review stage
- Extracting studies
- audited research papers
- 1
Why this is a research priority
Magnesium glycinate and bisglycinate are marketed as especially absorbable and sleep-promoting, but directly formulation-specific human evidence is sparse.
Questions being reviewed
- Does magnesium bisglycinate meaningfully improve insomnia symptoms or objective sleep outcomes?
- Is glycinate or bisglycinate more bioavailable than other magnesium salts in direct human comparisons?
- What do short trial duration, self-reported symptoms, kidney function, and medicine interactions mean for safety and interpretation?
Magnesium citrate
- Review stage
- Extracting studies
- audited research papers
- 4
Why this is a research priority
Magnesium citrate has direct absorption and migraine trials, but improved magnesium exposure is often mistaken for proof of broad clinical benefit.
Questions being reviewed
- How does citrate absorption compare with oxide and other oral forms?
- Does magnesium citrate reduce migraine frequency, and at what dose and tolerability cost?
- Do changes in blood or urine magnesium translate into blood-pressure, arterial, or other clinical benefit?
03 / SOURCES
Research standards
The review begins with federal evidence summaries and PubMed records, then moves to trial-level extraction. Product claims or another publisher’s evidence grade are not copied into the ledger.