Research review priorities
Supplement research priorities
These are research priorities, not recommendations. We selected decisions where public interest, plausible benefit, evidence maturity, and safety stakes make a careful synthesis especially useful.
- priority dossiers
- 148
- claim-level questions
- 444
- study extraction underway
- 148
01 / PRIORITY
How priorities were selected
Priority reflects relevance to healthy aging, frequency of real-world use, maturity of human evidence, the cost of a wrong decision, and the need to separate a valid narrow use from broader marketing claims. It does not rank efficacy or imply that everyone should take the product.
02 / EXTRACTION
What happens next
For every question, we screen the PubMed candidate set, connect multiple publications from the same trial, extract population, dose, comparator, duration, outcomes, harms, and funding, then synthesize supportive, mixed, negative, and safety findings together.
Only screened studies enter audited study and participant totals. Search-result counts and the papers listed here as questions never become evidence by themselves.Casein protein
- Review stage
- Extracting studies
- audited research papers
- 3
Why this is a research priority
Casein is promoted for a special pre-sleep anabolic window, but timing trials are small and often show that daily protein adequacy matters more than bedtime ingestion.
Questions being reviewed
- Does pre-sleep casein improve long-term muscle and strength more than the same dose earlier in the day?
- Does casein improve next-day soreness, performance, or clinically meaningful recovery?
- Does bedtime casein alter appetite, food intake, metabolism, or fat loss?
Soy protein
- Review stage
- Extracting studies
- audited research papers
- 3
Why this is a research priority
Soy protein has a modest LDL-lowering effect and can support training adaptations, but source comparisons change when leucine and total protein are matched.
Questions being reviewed
- How much does replacing non-soy protein with soy protein lower LDL and total cholesterol?
- Does soy support resistance-training gains comparably to whey when dose and leucine are matched?
- Do short lipid or body-composition changes establish cardiovascular or broader health outcomes?
Pea protein
- Review stage
- Extracting studies
- audited research papers
- 3
Why this is a research priority
Pea protein can be a practical alternative to whey, but trials are few, often manufacturer-funded, and frequently lack a nonprotein control or rely on subgroup and biomarker findings.
Questions being reviewed
- Does pea protein add muscle or strength beyond resistance training and an adequate diet?
- Is pea protein comparable with whey when total protein, leucine, and calories are matched?
- Do soreness or performance improve, and are findings replicated independently of manufacturers?
Lactobacillus rhamnosus GG (LGG)
- Review stage
- Extracting studies
- audited research papers
- 3
Why this is a research priority
LGG is a specific strain whose pooled pediatric gastroenteritis signal is heterogeneous and conflicts with a large, rigorous null U.S. trial.
Questions being reviewed
- Does LGG shorten acute pediatric gastroenteritis in the population and care setting at issue?
- Does LGG prevent antibiotic-associated diarrhea, and how robust are the pediatric estimates?
- Which strain identity, viable dose, host risks, and product-storage conditions constrain use?
Bifidobacterium animalis subsp. lactis
- Review stage
- Extracting studies
- audited research papers
- 2
Why this is a research priority
B. animalis subsp. lactis includes distinct strains, while two substantial HN019 constipation trials failed their prespecified primary analyses despite an earlier post hoc signal.
Questions being reviewed
- Does a defined B. animalis subsp. lactis strain improve complete spontaneous bowel movements in functional constipation?
- Are effects reproducible at the labeled strain, viable dose, duration, and baseline stool frequency?
- What host-risk precautions apply, and are results independently replicated beyond manufacturer-linked trials?
03 / SOURCES
Research standards
The review begins with federal evidence summaries and PubMed records, then moves to trial-level extraction. Product claims or another publisher’s evidence grade are not copied into the ledger.