Research review priorities
Supplement research priorities
These are research priorities, not recommendations. We selected decisions where public interest, plausible benefit, evidence maturity, and safety stakes make a careful synthesis especially useful.
- priority dossiers
- 148
- claim-level questions
- 444
- study extraction underway
- 148
01 / PRIORITY
How priorities were selected
Priority reflects relevance to healthy aging, frequency of real-world use, maturity of human evidence, the cost of a wrong decision, and the need to separate a valid narrow use from broader marketing claims. It does not rank efficacy or imply that everyone should take the product.
02 / EXTRACTION
What happens next
For every question, we screen the PubMed candidate set, connect multiple publications from the same trial, extract population, dose, comparator, duration, outcomes, harms, and funding, then synthesize supportive, mixed, negative, and safety findings together.
Only screened studies enter audited study and participant totals. Search-result counts and the papers listed here as questions never become evidence by themselves.Turmeric/curcumin
- Review stage
- Extracting studies
- audited research papers
- 4
Why this is a research priority
Many positive small trials use non-equivalent enhanced-absorption formulations, making effect size and generalizability difficult to interpret.
Questions being reviewed
- Does curcumin reduce osteoarthritis pain or improve function versus placebo or usual care?
- Are changes in inflammatory or metabolic biomarkers clinically meaningful?
- How do formulation, piperine, liver injury, and anticoagulants change the decision?
Coenzyme Q10
- Review stage
- Extracting studies
- audited research papers
- 5
Why this is a research priority
Frequently promoted for statin symptoms, energy, heart failure, and aging, but indications and formulations require separation.
Questions being reviewed
- Does adjunctive CoQ10 improve symptoms, hospitalization, or survival in heart failure?
- Does CoQ10 reduce statin-associated muscle symptoms in blinded trials?
- Is there evidence for general energy or longevity benefits in healthy adults?
Glucosamine/chondroitin
- Review stage
- Extracting studies
- audited research papers
- 5
Why this is a research priority
Osteoarthritis results differ by salt, product, comparator, and geography; observational mortality findings are not treatment evidence.
Questions being reviewed
- Which glucosamine products improve osteoarthritis pain or function?
- Does long-term use slow structural joint progression?
- How should observational mortality associations and anticoagulant safety be interpreted?
Ashwagandha
- Review stage
- Extracting studies
- audited research papers
- 6
Why this is a research priority
High consumer interest and many short, product-specific trials coexist with thyroid, liver, sedation, and pregnancy concerns.
Questions being reviewed
- Do standardized extracts meaningfully reduce stress or anxiety symptoms?
- What evidence supports sleep or exercise-performance benefits?
- What do thyroid, liver-injury, sedation, and pregnancy signals mean for safety?
Collagen peptides
- Review stage
- Extracting studies
- audited research papers
- 5
Why this is a research priority
Popular across skin, joints, bone, and muscle, with small effects and product-specific evidence that need plain-language context.
Questions being reviewed
- Do oral collagen peptides meaningfully change skin hydration, elasticity, or wrinkles?
- Do collagen products reduce joint pain or improve function?
- Do collagen supplements add muscle or bone benefit beyond adequate protein and training?
03 / SOURCES
Research standards
The review begins with federal evidence summaries and PubMed records, then moves to trial-level extraction. Product claims or another publisher’s evidence grade are not copied into the ledger.